Antibacterial effect of celery leaf extract (Apium graveolens L.) against Staphylococcus aureus in vitro

Staphylococcus aureus is a bacterium that causes various oral infections. Infections caused by S. are difficult to treat because they susceptible becoming resistant antibiotics. Oral infection can be prevented preventing plaque buildup with mouthwash, one of which chlorhexidine. Chlorhexidine reported have side effects in the short and long term. Therefore, it necessary search for natural ingredients easy obtain cheap as an alternative mouthwash prevention plaque, celery leaf. Celery leaves contain flavonoids, saponins, tannins antibacterial compounds. Purpose: This study aimed analyze activity leaf extract against growth aureus. Methods: were extracted using maceration method 96% ethanol. Inhibition test disc diffusion on MHA media has been overgrown The concentrations used 5%, 10%, 20%, 40%. research data analyzed SPSS. Results: showed there was inhibition zone formed around paper disk at concentration 20% 40% extract. results analysis significant differences (p>0.05) all treatment groups except between negative control, 5% group, 10% group. Conclusion: (Apium graveolens L.) greatest but still lower than